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Winston-Salem directions, for your exploring pleasure

401 North Main Street,
Winston-Salem, NC 27101
(336) 724-1009

A Winston-Salem Map For You

With its Art Deco architecture, Kimpton Cardinal Hotel stands apart in the Winston-Salem skyline, so you shouldn’t have any trouble finding us. Once you do, there’s plenty to explore on foot throughout our vibrant downtown neighborhood, from indoor-outdoor restaurants on Fourth Street to the Arts District centered around Sixth and Trade streets to the coffeehouses and bars of Burke Street. Farther afield, don’t miss historic Old Salem Museums & Gardens and Reynolda House Museum of Art — the estate and 60-room “bungalow” built by tobacco tycoon R.J. Reynolds and his wife, Katharine. Farther afield, you’ll find Yadkin Valley wine country, producing varieties from Aleatico to Zinfandel. For a mid-size city, Winston-Salem has a surprising variety of ways to stir your imagination.

From The West

  • Take I-40 E towards Winston-Salem/Greensboro
  • Take US-421 S towards Downtown Winston-Salem
  • Take Exit 5D toward Downtown (stay in left lane)
  • Merge onto S. Main St.
  • Kimpton Cardinal Hotel will be 1/2 mile ahead on your right.

From The East (PTI Airport, and RDU Airport)

  • Take I-40 W towards Greensboro/Winston-Salem
  • Merge right onto 40BUS W/US-421 N (follow signs for I-40 Business/Kernersville/Winston-Salem Downtown)
  • Take Exit 5D for Main St. toward Downtown
  • Turn right onto S. Main St.
  • Kimpton Cardinal Hotel will be 1/2 mile ahead on your right.

From The South (CLT airport)

  • Take I-85 N toward Greensboro
  • Keep right at the fork to continue on I-85BUS N/US-52N (follow signs for Interstate 85 Business/Lexington/Winston-Salem)
  • Keep left to continue on US-52 N
  • Take exit 109B for I-40 BUS W/US-158 W/US-421 N/NC 150 W toward Downtown
  • Take Exit 5D for Main St. toward Downtown
  • Kimpton Cardinal Hotel will be 1/2 mile ahead on your right.

From The North

  • Take I-85 S towards Durham
  • Merge onto I-40 W towards Greensboro/Winston-Salem
  • Merge right onto 40BUS W/US-421 N (follow signs for I-40 Business/Kernersville/Winston-Salem Downtown)
  • Take Exit 5D for Main St. toward Downtown
  • Turn right onto S. Main St.
  • Kimpton Cardinal Hotel will be 1/2 mile ahead on your right.